Cargando…

DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus

OBJECTIVES: Systemic lupus erythematosus (SLE) is a chronic autoimmune condition with heterogeneous presentation and complex aetiology where DNA methylation changes are emerging as a contributing factor. In order to discover novel epigenetic associations and investigate their relationship to genetic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Imgenberg-Kreuz, Juliana, Carlsson Almlöf, Jonas, Leonard, Dag, Alexsson, Andrei, Nordmark, Gunnel, Eloranta, Maija-Leena, Rantapää-Dahlqvist, Solbritt, Bengtsson, Anders A, Jönsen, Andreas, Padyukov, Leonid, Gunnarsson, Iva, Svenungsson, Elisabet, Sjöwall, Christopher, Rönnblom, Lars, Syvänen, Ann-Christine, Sandling, Johanna K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2018
Materias:	Basic and Translational Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909746/ https://www.ncbi.nlm.nih.gov/pubmed/29437559 http://dx.doi.org/10.1136/annrheumdis-2017-212379

Ejemplares similares

Novel risk genes for systemic lupus erythematosus predicted by random forest classification
por: Almlöf, Jonas Carlsson, et al.
Publicado: (2017)

Variants in BANK1 are associated with lupus nephritis of European ancestry
por: Bolin, Karin, et al.
Publicado: (2021)

Association of STAT4 Polymorphism with Severe Renal Insufficiency in Lupus Nephritis
por: Bolin, Karin, et al.
Publicado: (2013)

Shared and Unique Patterns of DNA Methylation in Systemic Lupus Erythematosus and Primary Sjögren's Syndrome
por: Imgenberg-Kreuz, Juliana, et al.
Publicado: (2019)

Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus
por: Almlöf, Jonas Carlsson, et al.
Publicado: (2019)

Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis
por: Leonard, Dag, et al.
Publicado: (2018)

Contributions of de novo variants to systemic lupus erythematosus
por: Almlöf, Jonas Carlsson, et al.
Publicado: (2020)

High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus
por: Reid, Sarah, et al.
Publicado: (2020)

Genome-wide DNA methylation analysis in multiple tissues in primary Sjögren's syndrome reveals regulatory effects at interferon-induced genes
por: Imgenberg-Kreuz, Juliana, et al.
Publicado: (2016)

Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease
por: Yavuz, Sule, et al.
Publicado: (2022)

DNA Methylation-Based Interferon Scores Associate With Sub-Phenotypes in Primary Sjögren’s Syndrome
por: Imgenberg-Kreuz, Juliana, et al.
Publicado: (2021)

Sex differences in clinical presentation of systemic lupus erythematosus
por: Ramírez Sepúlveda, Jorge I., et al.
Publicado: (2019)

Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations
por: Wang, Chuan, et al.
Publicado: (2013)

Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling
por: Lundtoft, Christian, et al.
Publicado: (2020)

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE
por: Sandling, Johanna K, et al.
Publicado: (2011)

Toll-like receptors revisited; a possible role for TLR1 in lupus nephritis
por: Yavuz, Sule, et al.
Publicado: (2021)

A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts
por: Farias, Fabiana H. G., et al.
Publicado: (2018)

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5
por: Sigurdsson, Snaevar, et al.
Publicado: (2008)

Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus
por: Odqvist, Lina, et al.
Publicado: (2019)

Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing
por: Sandling, Johanna K, et al.
Publicado: (2021)

Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus
por: Jönsen, Andreas, et al.
Publicado: (2011)

Interaction between the STAT4 rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus
por: Reid, Sarah, et al.
Publicado: (2021)

B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus
por: Hedenstedt, Anna, et al.
Publicado: (2023)

Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjögren's Syndrome
por: Lundtoft, Christian, et al.
Publicado: (2022)

Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases
por: Lundtoft, Christian, et al.
Publicado: (2022)

Four Systemic Lupus Erythematosus Subgroups, Defined by Autoantibodies Status, Differ Regarding HLA‐DRB1 Genotype Associations and Immunological and Clinical Manifestations
por: Diaz‐Gallo, Lina‐Marcela, et al.
Publicado: (2021)

Quick Systemic Lupus Activity Questionnaire (Q-SLAQ): a simplified version of SLAQ for patient-reported disease activity
por: Svenungsson, Elisabet, et al.
Publicado: (2021)

Genetics and epigenetics in primary Sjögren’s syndrome
por: Imgenberg-Kreuz, Juliana, et al.
Publicado: (2021)

C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205
por: Enocsson, Helena, et al.
Publicado: (2021)

Plasmacytoid dendritic cells and RNA-containing immune complexes drive expansion of peripheral B cell subsets with an SLE-like phenotype
por: Berggren, Olof, et al.
Publicado: (2017)

Case definitions in Swedish register data to identify systemic lupus erythematosus
por: Arkema, Elizabeth V, et al.
Publicado: (2016)

De novo lupus nephritis during treatment with belimumab
por: Parodis, Ioannis, et al.
Publicado: (2020)

Protein and DNA methylation-based scores as surrogate markers for interferon system activation in patients with primary Sjögren’s syndrome
por: Björk, Albin, et al.
Publicado: (2020)

Comparison of Surrogate Markers of the Type I Interferon Response and Their Ability to Mirror Disease Activity in Systemic Lupus Erythematosus
por: Enocsson, Helena, et al.
Publicado: (2021)

Histological antiphospholipid-associated nephropathy versus lupus nephritis in patients with systemic lupus erythematosus: an observational cross-sectional study with longitudinal follow-up
por: Gerhardsson, Jakob, et al.
Publicado: (2015)

Cause and consequences of the activated type I interferon system in SLE
por: Eloranta, Maija-Leena, et al.
Publicado: (2016)

Low-density granulocytes are related to shorter pregnancy duration but not to interferon alpha protein blood levels in systemic lupus erythematosus
por: Torell, Agnes, et al.
Publicado: (2023)

Abdominal obesity, gender and the risk of rheumatoid arthritis – a nested case–control study
por: Ljung, Lotta, et al.
Publicado: (2016)

Genetic Risk Factors in Lupus Nephritis and IgA Nephropathy – No Support of an Overlap
por: Vuong, Mai Tuyet, et al.
Publicado: (2010)

The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE
por: Hagberg, Niklas, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9drs5rtjvs6hn6fjkv3i08h8cm