Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 2*2) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography

E487K point mutation of aldehyde dehydrogenase (ALDH) 2 (ALDH2*2) in East Asians intrinsically lowers ALDH2 activity. ALDH2*2 is associated with diabetic cardiomyopathy. Diabetic patients exhibit heart failure of preserved ejection fraction (HFpEF) i.e. while the systolic heart function is preserved...

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Detalles Bibliográficos
Autores principales: Pan, Guodong, Munukutla, Srikar, Kar, Ananya, Gardinier, Joseph, Thandavarayan, Rajarajan A., Palaniyandi, Suresh Selvaraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909916/
https://www.ncbi.nlm.nih.gov/pubmed/29677191
http://dx.doi.org/10.1371/journal.pone.0195796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909916/
https://www.ncbi.nlm.nih.gov/pubmed/29677191
http://dx.doi.org/10.1371/journal.pone.0195796

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