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Salt bridges gate α-catenin activation at intercellular junctions

Cadherin complexes transduce force fluctuations at junctions to activate signals that reinforce stressed intercellular contacts. α-Catenin is an identified force transducer within cadherin complexes that is autoinhibited under low tension. Increased force triggers a conformational change that expose...

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Detalles Bibliográficos
Autores principales: Barrick, Samantha, Li, Jing, Kong, Xinyu, Ray, Alokananda, Tajkhorshid, Emad, Leckband, Deborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909925/
https://www.ncbi.nlm.nih.gov/pubmed/29142072
http://dx.doi.org/10.1091/mbc.E17-03-0168