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GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production
The diversion of the membrane-bound β-site amyloid precursor protein–(APP) cleaving enzyme (BACE1) from the endolysosomal pathway to recycling endosomes represents an important transport step in the regulation of amyloid beta (Aβ) production. However, the mechanisms that regulate endosome sorting of...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909931/ https://www.ncbi.nlm.nih.gov/pubmed/29142073 http://dx.doi.org/10.1091/mbc.E17-05-0270 |