Mapping mutational effects along the evolutionary landscape of HIV envelope

The immediate evolutionary space accessible to HIV is largely determined by how single amino acid mutations affect fitness. These mutational effects can shift as the virus evolves. However, the prevalence of such shifts in mutational effects remains unclear. Here, we quantify the effects on viral gr...

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Detalles Bibliográficos
Autores principales: Haddox, Hugh K, Dingens, Adam S, Hilton, Sarah K, Overbaugh, Julie, Bloom, Jesse D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910023/
https://www.ncbi.nlm.nih.gov/pubmed/29590010
http://dx.doi.org/10.7554/eLife.34420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910023/
https://www.ncbi.nlm.nih.gov/pubmed/29590010
http://dx.doi.org/10.7554/eLife.34420

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