Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation

Cyclooxygenase-2 (COX-2), with its main antifibrotic metabolite PGE(2), is regarded as an antifibrotic gene. Repressed COX-2 expression and deficient PGE(2) have been shown to contribute to the activation of lung fibroblasts and excessive deposition of collagen in pulmonary fibrosis. We have previou...

Descripción completa

Detalles Bibliográficos
Autores principales: Pasini, Alice, Brand, Oliver J., Jenkins, Gisli, Knox, Alan J., Pang, Linhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910054/
https://www.ncbi.nlm.nih.gov/pubmed/29555582
http://dx.doi.org/10.1016/j.bbagrm.2018.03.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910054/
https://www.ncbi.nlm.nih.gov/pubmed/29555582
http://dx.doi.org/10.1016/j.bbagrm.2018.03.007

Ejemplares similares