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Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation
Cyclooxygenase-2 (COX-2), with its main antifibrotic metabolite PGE(2), is regarded as an antifibrotic gene. Repressed COX-2 expression and deficient PGE(2) have been shown to contribute to the activation of lung fibroblasts and excessive deposition of collagen in pulmonary fibrosis. We have previou...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Pub. Co
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910054/ https://www.ncbi.nlm.nih.gov/pubmed/29555582 http://dx.doi.org/10.1016/j.bbagrm.2018.03.007 |