Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets

Both CC and CXC-class chemokines drive inflammatory disease. Tick salivary chemokine-binding proteins (CKBPs), or evasins, specifically bind subsets of CC- or CXC-chemokines, and could precisely target disease-relevant chemokines. Here we have used yeast surface display to identify two tick evasins:...

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Detalles Bibliográficos
Autores principales: Alenazi, Yara, Singh, Kamayani, Davies, Graham, Eaton, James R. O., Elders, Philip, Kawamura, Akane, Bhattacharya, Shoumo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910400/
https://www.ncbi.nlm.nih.gov/pubmed/29679010
http://dx.doi.org/10.1038/s41598-018-24568-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910400/
https://www.ncbi.nlm.nih.gov/pubmed/29679010
http://dx.doi.org/10.1038/s41598-018-24568-9

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