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Fluorophore labeling of a cell-penetrating peptide significantly alters the mode and degree of biomembrane interaction
The demand for highly efficient macromolecular drugs, used in the treatment of many severe diseases, is continuously increasing. However, the hydrophilic character and large molecular size of these drugs significantly limit their ability to permeate across cellular membranes and thus impede the drug...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910404/ https://www.ncbi.nlm.nih.gov/pubmed/29679078 http://dx.doi.org/10.1038/s41598-018-24154-z |