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Disruption of Hox9,10,11 function results in cellular level lineage infidelity in the kidney

Hox genes are important regulators of development. The 39 mammalian Hox genes have considerable functional overlap, greatly confounding their study. In this report, we generated mice with multiple combinations of paralogous and flanking Abd-B Hox gene mutations to investigate functional redundancies...

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Detalles Bibliográficos
Autores principales: Drake, Keri A., Adam, Mike, Mahoney, Robert, Potter, S. Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910417/
https://www.ncbi.nlm.nih.gov/pubmed/29679048
http://dx.doi.org/10.1038/s41598-018-24782-5