Systematic evaluation of RNA quality, microarray data reliability and pathway analysis in fresh, fresh frozen and formalin-fixed paraffin-embedded tissue samples

Formalin-fixed paraffin-embedded (FFPE) tissues are valuable resources commonly used in pathology. However, formalin fixation modifies nucleic acids challenging the isolation of high-quality RNA for genetic profiling. Here, we assessed feasibility and reliability of microarray studies analysing tran...

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Detalles Bibliográficos
Autores principales: Wimmer, Isabella, Tröscher, Anna R., Brunner, Florian, Rubino, Stephen J., Bien, Christian G., Weiner, Howard L., Lassmann, Hans, Bauer, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910432/
https://www.ncbi.nlm.nih.gov/pubmed/29679021
http://dx.doi.org/10.1038/s41598-018-24781-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910432/
https://www.ncbi.nlm.nih.gov/pubmed/29679021
http://dx.doi.org/10.1038/s41598-018-24781-6

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