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Targeting matrix metalloproteinases with novel diazepine substituted cinnamic acid derivatives: design, synthesis, in vitro and in silico studies
Lung cancer is the notable cause of cancer associated deaths worldwide. Recent studies revealed that the expression of matrix metalloproteinases (MMPs) is extremely high in lung tumors compared with non-malignant lung tissue. MMPs (-2 and -9) play an important part in tumor development and angiogene...
Autores principales: | Rathee, Dharmender, Lather, Viney, Grewal, Ajmer Singh, Dureja, Harish |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910448/ https://www.ncbi.nlm.nih.gov/pubmed/29679218 http://dx.doi.org/10.1186/s13065-018-0411-8 |
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