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Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis

Hemodynamic forces and Notch signaling are both known as key regulators of arterial remodeling and homeostasis. However, how these two factors integrate in vascular morphogenesis and homeostasis is unclear. Here, we combined experiments and modeling to evaluate the impact of the integration of mecha...

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Detalles Bibliográficos
Autores principales: Loerakker, Sandra, Stassen, Oscar M. J. A., ter Huurne, Fleur M., Boareto, Marcelo, Bouten, Carlijn V. C., Sahlgren, Cecilia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910818/
https://www.ncbi.nlm.nih.gov/pubmed/29610298
http://dx.doi.org/10.1073/pnas.1715277115