Comprehensive, high-resolution binding energy landscapes reveal context dependencies of transcription factor binding

Transcription factors (TFs) are primary regulators of gene expression in cells, where they bind specific genomic target sites to control transcription. Quantitative measurements of TF–DNA binding energies can improve the accuracy of predictions of TF occupancy and downstream gene expression in vivo...

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Detalles Bibliográficos
Autores principales: Le, Daniel D., Shimko, Tyler C., Aditham, Arjun K., Keys, Allison M., Longwell, Scott A., Orenstein, Yaron, Fordyce, Polly M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910820/
https://www.ncbi.nlm.nih.gov/pubmed/29588420
http://dx.doi.org/10.1073/pnas.1715888115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910820/
https://www.ncbi.nlm.nih.gov/pubmed/29588420
http://dx.doi.org/10.1073/pnas.1715888115

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