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Comprehensive, high-resolution binding energy landscapes reveal context dependencies of transcription factor binding
Transcription factors (TFs) are primary regulators of gene expression in cells, where they bind specific genomic target sites to control transcription. Quantitative measurements of TF–DNA binding energies can improve the accuracy of predictions of TF occupancy and downstream gene expression in vivo...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910820/ https://www.ncbi.nlm.nih.gov/pubmed/29588420 http://dx.doi.org/10.1073/pnas.1715888115 |