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Distinct thermodynamic signature of oligomer generation in the aggregation of the amyloid-β peptide

Mapping energy landscapes has proved to be a powerful tool for studying reaction mechanisms. Many complex biomolecular assembly processes, however, have remained challenging to access using this approach, including the aggregation of peptides and proteins into amyloid fibrils implicated in various d...

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Detalles Bibliográficos
Autores principales: Cohen, Samuel I. A., Cukalevski, Risto, Michaels, Thomas. C. T., Šarić, Anđela, Törnquist, Mattias, Vendruscolo, Michele, Dobson, Christopher M., Buell, Alexander K., Knowles, Tuomas P. J., Linse, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911155/
https://www.ncbi.nlm.nih.gov/pubmed/29581486
http://dx.doi.org/10.1038/s41557-018-0023-x