Inhibition of integrin α5β1 ameliorates VEGF-induced retinal neovascularization and leakage by suppressing NLRP3 inflammasome signaling in a mouse model

PURPOSE: To assess the effect of inhibiting integrin α5β1 by ATN-161 on vascular endothelial growth factor (VEGF)-induced neovascularization (NV) and leakage causing retinal detachment in adult Tet/opsin/VEGF transgenic mice, and characterize the underlying mechanism of its function. METHOD: Retinas...

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Detalles Bibliográficos
Autores principales: Sui, Ailing, Zhong, Yisheng, Demetriades, Anna M., Lu, Qing, Cai, Yujuan, Gao, Yushuo, Zhu, Yanji, Shen, Xi, Xie, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911279/
https://www.ncbi.nlm.nih.gov/pubmed/29502235
http://dx.doi.org/10.1007/s00417-018-3940-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911279/
https://www.ncbi.nlm.nih.gov/pubmed/29502235
http://dx.doi.org/10.1007/s00417-018-3940-x

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