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Intermolecular interaction as a direct measure of water solubility advantage of meloxicam cocrystalized with carboxylic acids
The solubility advantage (SA) of meloxicam cocrystalized with mono- and dicarboxylic acids was expressed in terms of equilibrium constants involving active pharmaceutical ingredient and coformer in aqueous solutions. It is argued that SA can be quantified by concentration of pairs formed in water. T...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Berlin Heidelberg
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911280/ https://www.ncbi.nlm.nih.gov/pubmed/29680958 http://dx.doi.org/10.1007/s00894-018-3649-0 |