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Thermodynamics of Amyloid-β Fibril Elongation: Atomistic Details of the Transition State
[Image: see text] Amyloid-β (Aβ) fibrils and plaques are one of the hallmarks of Alzheimer’s disease. While the kinetics of fibrillar growth of Aβ have been extensively studied, several vital questions remain. In particular, the atomistic origins of the Arrhenius barrier observed in experiments have...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical
Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911799/ https://www.ncbi.nlm.nih.gov/pubmed/29239603 http://dx.doi.org/10.1021/acschemneuro.7b00409 |