Acquired modification of sphingosine-1-phosphate lyase activity is not related to adrenal insufficiency

BACKGROUND: Congenital sphingosine-1-phosphate (S1P) lyase deficiency due to biallelic mutations in SGPL1 gene has recently been described in association with primary adrenal insufficiency and steroid-resistant nephrotic syndrome. S1P lyase, on the other hand, is therapeutically inhibited by fingoli...

Descripción completa

Detalles Bibliográficos
Autores principales: Sunter, Gulin, Enver, Ece Oge, Akbarzade, Azad, Turan, Serap, Vatansever, Pinar, Gunal, Dilek Ince, Haklar, Goncagul, Bereket, Abdullah, Agan, Kadriye, Guran, Tulay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911956/
https://www.ncbi.nlm.nih.gov/pubmed/29685115
http://dx.doi.org/10.1186/s12883-018-1049-9