Supramolecular assembly of the beta-catenin destruction complex and the effect of Wnt signaling on its localization, molecular size, and activity in vivo

Wnt signaling provides a paradigm for cell-cell signals that regulate embryonic development and stem cell homeostasis and are inappropriately activated in cancers. The tumor suppressors APC and Axin form the core of the multiprotein destruction complex, which targets the Wnt-effector beta-catenin fo...

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Detalles Bibliográficos
Autores principales: Schaefer, Kristina N., Bonello, Teresa T., Zhang, Shiping, Williams, Clara E., Roberts, David M., McKay, Daniel J., Peifer, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912785/
https://www.ncbi.nlm.nih.gov/pubmed/29641560
http://dx.doi.org/10.1371/journal.pgen.1007339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912785/
https://www.ncbi.nlm.nih.gov/pubmed/29641560
http://dx.doi.org/10.1371/journal.pgen.1007339

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