Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1’s Cytotoxic Potential

Tumor necrosis factor (TNF) is an inflammatory cytokine that can signal cell survival or cell death. The mechanisms that switch between these distinct outcomes remain poorly defined. Here, we show that the E3 ubiquitin ligase Mind Bomb-2 (MIB2) regulates TNF-induced cell death by inactivating RIPK1...

Descripción completa

Detalles Bibliográficos
Autores principales: Feltham, Rebecca, Jamal, Kunzah, Tenev, Tencho, Liccardi, Gianmaria, Jaco, Isabel, Domingues, Celia Monteiro, Morris, Otto, John, Sidonie Wicky, Annibaldi, Alessandro, Widya, Marcella, Kearney, Conor J., Clancy, Danielle, Elliott, Paul R., Glatter, Timo, Qiao, Qi, Thompson, Andrew J., Nesvizhskii, Alexey, Schmidt, Alexander, Komander, David, Wu, Hao, Martin, Seamus, Meier, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912950/
https://www.ncbi.nlm.nih.gov/pubmed/29642005
http://dx.doi.org/10.1016/j.celrep.2018.03.054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912950/
https://www.ncbi.nlm.nih.gov/pubmed/29642005
http://dx.doi.org/10.1016/j.celrep.2018.03.054

Ejemplares similares