Targeting GLP-1 receptor trafficking to improve agonist efficacy

Glucagon-like peptide-1 receptor (GLP-1R) activation promotes insulin secretion from pancreatic beta cells, causes weight loss, and is an important pharmacological target in type 2 diabetes (T2D). Like other G protein-coupled receptors, the GLP-1R undergoes agonist-mediated endocytosis, but the func...

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Detalles Bibliográficos
Autores principales: Jones, Ben, Buenaventura, Teresa, Kanda, Nisha, Chabosseau, Pauline, Owen, Bryn M., Scott, Rebecca, Goldin, Robert, Angkathunyakul, Napat, Corrêa Jr, Ivan R., Bosco, Domenico, Johnson, Paul R., Piemonti, Lorenzo, Marchetti, Piero, Shapiro, A. M. James, Cochran, Blake J., Hanyaloglu, Aylin C., Inoue, Asuka, Tan, Tricia, Rutter, Guy A., Tomas, Alejandra, Bloom, Stephen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913239/
https://www.ncbi.nlm.nih.gov/pubmed/29686402
http://dx.doi.org/10.1038/s41467-018-03941-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913239/
https://www.ncbi.nlm.nih.gov/pubmed/29686402
http://dx.doi.org/10.1038/s41467-018-03941-2

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