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Lysosomal damage after spinal cord injury causes accumulation of RIPK1 and RIPK3 proteins and potentiation of necroptosis
Necroptosis, a regulated necrosis pathway mediated by the receptor-interacting protein kinases 1 and 3 (RIPK1 and RIPK3), is induced following spinal cord injury (SCI) and thought to contribute to neuronal and glial cell death. However, mechanisms leading to activation of necroptosis after SCI remai...
Autores principales: | Liu, Shuo, Li, Yun, Choi, Harry M. C., Sarkar, Chinmoy, Koh, Eugene Y., Wu, Junfang, Lipinski, Marta M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913300/ https://www.ncbi.nlm.nih.gov/pubmed/29686269 http://dx.doi.org/10.1038/s41419-018-0469-1 |
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