Selection and Neutral Mutations Drive Pervasive Mutability Losses in Long-Lived Anti-HIV B-Cell Lineages

High-affinity antibodies arise within weeks of infection from the evolution of B-cell receptors under selection to improve antigen recognition. This rapid adaptation is enabled by the distribution of highly mutable “hotspot” motifs in B-cell receptor genes. High mutability in antigen-binding regions...

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Detalles Bibliográficos
Autores principales: Vieira, Marcos C, Zinder, Daniel, Cobey, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913683/
https://www.ncbi.nlm.nih.gov/pubmed/29688540
http://dx.doi.org/10.1093/molbev/msy024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913683/
https://www.ncbi.nlm.nih.gov/pubmed/29688540
http://dx.doi.org/10.1093/molbev/msy024

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