Extrahepatic cytochrome P450s play an insignificant role in triptolide-induced toxicity

BACKGROUND: Triptolide, an active ingredient of Chinese medicine plant Tripterygium wilfordii Hook.f., has been shown to exert anti-tumor, immunosuppressive, anti-inflammatory, and anti-fertility pharmacological effects. However, triptolide also causes severe side effects, which are manifested as to...

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Detalles Bibliográficos
Autores principales: Wei, Yuan, Wang, Dujun, Chen, Meng, Ouyang, Zhen, Wang, Shuo, Gu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913882/
https://www.ncbi.nlm.nih.gov/pubmed/29713369
http://dx.doi.org/10.1186/s13020-018-0179-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913882/
https://www.ncbi.nlm.nih.gov/pubmed/29713369
http://dx.doi.org/10.1186/s13020-018-0179-8

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