Repurposing and Reformulation of the Antiparasitic Agent Flubendazole for Treatment of Cryptococcal Meningoencephalitis, a Neglected Fungal Disease

Current therapeutic options for cryptococcal meningitis are limited by toxicity, global supply, and emergence of resistance. There is an urgent need to develop additional antifungal agents that are fungicidal within the central nervous system and preferably orally bioavailable. The benzimidazoles ha...

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Detalles Bibliográficos
Autores principales: Nixon, Gemma L., McEntee, Laura, Johnson, Adam, Farrington, Nicola, Whalley, Sarah, Livermore, Joanne, Natal, Cristien, Washbourn, Gina, Bibby, Jaclyn, Berry, Neil, Lestner, Jodi, Truong, Megan, Owen, Andrew, Lalloo, David, Charles, Ian, Hope, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913986/
https://www.ncbi.nlm.nih.gov/pubmed/29311092
http://dx.doi.org/10.1128/AAC.01909-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913986/
https://www.ncbi.nlm.nih.gov/pubmed/29311092
http://dx.doi.org/10.1128/AAC.01909-17

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