Recurrent inhibition of mitochondrial complex III induces chronic pulmonary vasoconstriction and glycolytic switch in the rat lung

BACKGROUND: Pulmonary arterial hypertension (PAH) is a fatal disease; however, the mechanisms directly involved in triggering and the progression of PAH are not clear. Based on previous studies that demonstrated a possible role of mitochondrial dysfunction in the pathogenesis of PAH, we investigated...

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Detalles Bibliográficos
Autores principales: Rafikova, Olga, Srivastava, Anup, Desai, Ankit A., Rafikov, Ruslan, Tofovic, Stevan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914012/
https://www.ncbi.nlm.nih.gov/pubmed/29685148
http://dx.doi.org/10.1186/s12931-018-0776-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914012/
https://www.ncbi.nlm.nih.gov/pubmed/29685148
http://dx.doi.org/10.1186/s12931-018-0776-1

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