ATR kinase inhibitors NVP-BEZ235 and AZD6738 effectively penetrate the brain after systemic administration

Ataxia Telangiectasia and Rad3 related protein (ATR) is a central mediator of the response to DNA damage that may cause the quiescent resistance of cancer initiating cells to genotoxic radiotherapy. NVP-BEZ235 is a dual PI3K/mTOR inhibitor that also effectively targets ATR with IC(50) = 21 × 10(− 9)...

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Detalles Bibliográficos
Autores principales: Fròsina, Guido, Profumo, Aldo, Marubbi, Daniela, Marcello, Diana, Ravetti, Jean Louis, Daga, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914052/
https://www.ncbi.nlm.nih.gov/pubmed/29685176
http://dx.doi.org/10.1186/s13014-018-1020-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914052/
https://www.ncbi.nlm.nih.gov/pubmed/29685176
http://dx.doi.org/10.1186/s13014-018-1020-3

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