Human Abuse Potential of the New Opioid Analgesic Molecule NKTR-181 Compared with Oxycodone

OBJECTIVE: Evaluate the human abuse potential, pharmacokinetics, pharmacodynamics, and safety of NKTR-181, a novel mu-opioid agonist molecule, relative to oxycodone. DESIGN: This randomized, single-center, double-blind, active- and placebo-controlled five-period crossover study enrolled healthy, adu...

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Detalles Bibliográficos
Autores principales: Webster, Lynn, Henningfield, Jack, Buchhalter, August R, Siddhanti, Suresh, Lu, Lin, Odinecs, Aleksandrs, Di Fonzo, Carlo J, Eldon, Michael A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
OPIOIDS & SUBSTANCE USE DISORDERS SECTION
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914314/
https://www.ncbi.nlm.nih.gov/pubmed/28340145
http://dx.doi.org/10.1093/pm/pnw344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914314/
https://www.ncbi.nlm.nih.gov/pubmed/28340145
http://dx.doi.org/10.1093/pm/pnw344

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