Novel C(H)1:C(L) interfaces that enhance correct light chain pairing in heterodimeric bispecific antibodies

Targeting two unique antigens with a single bispecific antibody is an attractive approach with potential broad therapeutic applicability. However, the production of heterodimeric bispecific antibodies (bsAbs) presents a challenge, requiring the co-expression and accurate pairing of two distinct heav...

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Detalles Bibliográficos
Autores principales: Bönisch, Maximilian, Sellmann, Carolin, Maresch, Daniel, Halbig, Claudia, Becker, Stefan, Toleikis, Lars, Hock, Björn, Rüker, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914326/
https://www.ncbi.nlm.nih.gov/pubmed/28981885
http://dx.doi.org/10.1093/protein/gzx044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914326/
https://www.ncbi.nlm.nih.gov/pubmed/28981885
http://dx.doi.org/10.1093/protein/gzx044

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