Cargando…

Novel C(H)1:C(L) interfaces that enhance correct light chain pairing in heterodimeric bispecific antibodies

Targeting two unique antigens with a single bispecific antibody is an attractive approach with potential broad therapeutic applicability. However, the production of heterodimeric bispecific antibodies (bsAbs) presents a challenge, requiring the co-expression and accurate pairing of two distinct heav...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bönisch, Maximilian, Sellmann, Carolin, Maresch, Daniel, Halbig, Claudia, Becker, Stefan, Toleikis, Lars, Hock, Björn, Rüker, Florian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914326/ https://www.ncbi.nlm.nih.gov/pubmed/28981885 http://dx.doi.org/10.1093/protein/gzx044

Ejemplares similares

Structural basis of a novel heterodimeric Fc for bispecific antibody production
por: Wei, Hudie, et al.
Publicado: (2017)

An antibody with Fab-constant domains exchanged for a pair of C(H)3 domains
por: Wozniak-Knopp, Gordana, et al.
Publicado: (2018)

Greatest Hits—Innovative Technologies for High Throughput Identification of Bispecific Antibodies
por: Hofmann, Tim, et al.
Publicado: (2020)

Intein mediated high throughput screening for bispecific antibodies
por: Hofmann, Tim, et al.
Publicado: (2020)

Bispecific antibodies with Fab-arms featuring exchanged antigen-binding constant domains
por: Benedetti, Filippo, et al.
Publicado: (2021)

Bispecific T-Cell Engagers Targeting Membrane-Bound IgE
por: Rodak, Aleksandra, et al.
Publicado: (2021)

Characterization of high-molecular weight by-products in the production of a trivalent bispecific 2+1 heterodimeric antibody
por: Cramer, Dario A. T., et al.
Publicado: (2023)

Bispecific mAb(2) Antibodies Targeting CD59 Enhance the Complement-Dependent Cytotoxicity Mediated by Rituximab
por: Stadlbauer, Katharina, et al.
Publicado: (2022)

Bispecific antibodies—effects of point mutations on C(H)3-C(H)3 interface stability
por: Pomarici, Nancy D, et al.
Publicado: (2022)

EFab domain substitution as a solution to the light-chain pairing problem of bispecific antibodies
por: Cooke, Heather A., et al.
Publicado: (2018)

Efficient biosynthesis of heterodimeric C(3)-aryl pyrroloindoline alkaloids
por: Tian, Wenya, et al.
Publicado: (2018)

Characterization of light chain c-terminal extension sequence variant in one bispecific antibody
por: Lin, Jun, et al.
Publicado: (2022)

CDR loop interactions can determine heavy and light chain pairing preferences in bispecific antibodies
por: Fernández-Quintero, Monica L., et al.
Publicado: (2022)

Modulating organelle distribution using light-inducible heterodimerization in C. elegans
por: Dansen, Tobias B., et al.
Publicado: (2021)

A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells
por: Harris, Katherine E., et al.
Publicado: (2021)

Elucidating heavy/light chain pairing preferences to facilitate the assembly of bispecific IgG in single cells
por: Joshi, Kamal Kishore, et al.
Publicado: (2019)

Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities
por: Yanakieva, Desislava, et al.
Publicado: (2022)

Notch Intracellular Domains form Transcriptionally Active Heterodimeric Complexes on Sequence-paired Sites
por: Gazdik, Tana R., et al.
Publicado: (2023)

Ion Pairing and Adsorption of Azo Dye/C(16)TAB Surfactants at the Air–Water Interface
por: Streubel, Saskia, et al.
Publicado: (2017)

Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the C(H)1-C(λ) interface
por: Bagert, John D., et al.
Publicado: (2023)

Tethered-variable C(L) bispecific IgG: an antibody platform for rapid bispecific antibody screening
por: Kim, Hok Seon, et al.
Publicado: (2017)

The Function of Heterodimeric AP-1 Comprised of c-Jun and c-Fos in Activin Mediated Spemann Organizer Gene Expression
por: Lee, Sung-Young, et al.
Publicado: (2011)

Heterodimeric Plasmonic Nanogaps for Biosensing
por: Chatterjee, Sharmistha, et al.
Publicado: (2018)

Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming in C. elegans
por: Liu, Haowen, et al.
Publicado: (2019)

Strategies for Bispecific Single Chain Antibody in Cancer Immunotherapy
por: Zhou, Shu-juan, et al.
Publicado: (2017)

Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics
por: Froning, Karen, et al.
Publicado: (2020)

Targeted Phagocytosis Induction for Cancer Immunotherapy via Bispecific MerTK-Engaging Antibodies
por: Carrara, Stefania C., et al.
Publicado: (2022)

Heterodimerization of Munc13 C(2)A domain with RIM regulates synaptic vesicle docking and priming
por: Camacho, Marcial, et al.
Publicado: (2017)

Heterodimeric DNA motif synthesis and validations
por: Wong, Ka-Chun, et al.
Publicado: (2019)

Heterodimeric IL-15 in Cancer Immunotherapy
por: Bergamaschi, Cristina, et al.
Publicado: (2021)

A generic approach to engineer antibody pH-switches using combinatorial histidine scanning libraries and yeast display
por: Schröter, Christian, et al.
Publicado: (2014)

Evaluation of the antitumor effects of c-Myc-Max heterodimerization inhibitor 100258-F4 in ovarian cancer cells
por: Wang, Jiandong, et al.
Publicado: (2014)

The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts
por: Lisse, Thomas S, et al.
Publicado: (2014)

Selection of Antibodies with Tailored Properties by Application of High-Throughput Multiparameter Fluorescence-Activated Cell Sorting of Yeast-Displayed Immune Libraries
por: Schröter, Christian, et al.
Publicado: (2018)

Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition
por: Lipinski, Britta, et al.
Publicado: (2023)

Modulation of ERCC1-XPF Heterodimerization Inhibition via Structural Modification of Small Molecule Inhibitor Side-Chains
por: Weilbeer, Claudia, et al.
Publicado: (2022)

Suppression of c-Met-Overexpressing Tumors by a Novel c-Met/CD3 Bispecific Antibody
por: Huang, Lei, et al.
Publicado: (2020)

Emerging Roles of TWIK-1 Heterodimerization in the Brain
por: Cho, Chang-Hoon, et al.
Publicado: (2017)

Early Archean origin of heterodimeric Photosystem I
por: Cardona, Tanai
Publicado: (2018)

Quantitative Supramolecular Heterodimerization for Efficient Energy Transfer
por: Wu, Guanglu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ccist68karthc3e8c4l4576vk2