Long-Term Safety and Efficacy of Subcutaneous Methylnaltrexone in Patients with Opioid-Induced Constipation and Chronic Noncancer Pain: A Phase 3, Open-Label Trial

Objective. Methylnaltrexone, a peripherally acting µ-opioid receptor antagonist, alleviates opioid-induced constipation. Understanding its long-term safety and efficacy profile in patients with chronic noncancer pain is warranted given the persistence of opioid-induced constipation. Methods. In this...

Descripción completa

Detalles Bibliográficos
Autores principales: Webster, Lynn R., Michna, Edward, Khan, Arif, Israel, Robert J., Harper, Joseph R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
OPIOIDS & SUBSTANCE USE DISORDERS SECTION
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914419/
https://www.ncbi.nlm.nih.gov/pubmed/28810695
http://dx.doi.org/10.1093/pm/pnx148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914419/
https://www.ncbi.nlm.nih.gov/pubmed/28810695
http://dx.doi.org/10.1093/pm/pnx148

Ejemplares similares