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Long-Term Safety and Efficacy of Subcutaneous Methylnaltrexone in Patients with Opioid-Induced Constipation and Chronic Noncancer Pain: A Phase 3, Open-Label Trial

Objective. Methylnaltrexone, a peripherally acting µ-opioid receptor antagonist, alleviates opioid-induced constipation. Understanding its long-term safety and efficacy profile in patients with chronic noncancer pain is warranted given the persistence of opioid-induced constipation. Methods. In this...

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Detalles Bibliográficos
Autores principales:	Webster, Lynn R., Michna, Edward, Khan, Arif, Israel, Robert J., Harper, Joseph R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	OPIOIDS & SUBSTANCE USE DISORDERS SECTION
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914419/ https://www.ncbi.nlm.nih.gov/pubmed/28810695 http://dx.doi.org/10.1093/pm/pnx148

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