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DNA Polymerase θ Increases Mutational Rates in Mitochondrial DNA

[Image: see text] Replication and maintenance of mitochondrial DNA (mtDNA) is essential for cellular function, yet few DNA polymerases are known to function in mitochondria. Here, we conclusively demonstrate that DNA polymerase θ (Polθ) localizes to mitochondria and explore whether this protein is o...

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Detalles Bibliográficos
Autores principales:	Wisnovsky, Simon, Sack, Tanja, Pagliarini, David J., Laposa, Rebecca R., Kelley, Shana O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914477/ https://www.ncbi.nlm.nih.gov/pubmed/29509408 http://dx.doi.org/10.1021/acschembio.8b00072

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