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Highly multiplexed single-cell in situ RNA and DNA analysis with bioorthogonal cleavable fluorescent oligonucleotides

The ability to profile transcripts and genomic loci comprehensively in single cells in situ is essential to advance our understanding of normal physiology and disease pathogenesis. Here we report a highly multiplexed single-cell in situ RNA and DNA analysis approach using bioorthogonal cleavable flu...

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Detalles Bibliográficos
Autores principales: Mondal, Manas, Liao, Renjie, Nazaroff, Christopher D., Samuel, Adam D., Guo, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914540/
https://www.ncbi.nlm.nih.gov/pubmed/29732074
http://dx.doi.org/10.1039/c7sc05089e