DNA methylation of the Oct4A enhancers in embryonal carcinoma cells after etoposide treatment is associated with alternative splicing and altered pluripotency in reversibly senescent cells

The epigenetic mechanisms underlying chemoresistance in cancer cells resulting from drug-induced reversible senescence are poorly understood. Chemoresistant ESC-like embryonal carcinoma PA1 cells treated with etoposide (ETO) were previously found to undergo prolonged G2 arrest with transient p53-dep...

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Detalles Bibliográficos
Autores principales: Baryshev, Mikhail, Inashkina, Inna, Salmina, Kristine, Huna, Anda, Jackson, Thomas R, Erenpreisa, Jekaterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914730/
https://www.ncbi.nlm.nih.gov/pubmed/29372665
http://dx.doi.org/10.1080/15384101.2018.1426412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914730/
https://www.ncbi.nlm.nih.gov/pubmed/29372665
http://dx.doi.org/10.1080/15384101.2018.1426412

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