Rilmenidine promotes MTOR-independent autophagy in the mutant SOD1 mouse model of amyotrophic lateral sclerosis without slowing disease progression

Macroautophagy/autophagy is the main intracellular catabolic pathway in neurons that eliminates misfolded proteins, aggregates and damaged organelles associated with ageing and neurodegeneration. Autophagy is regulated by both MTOR-dependent and -independent pathways. There is increasing evidence th...

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Detalles Bibliográficos
Autores principales: Perera, Nirma D., Sheean, Rebecca K., Lau, Chew L., Shin, Yea Seul, Beart, Philip M., Horne, Malcolm K., Turner, Bradley J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Papers - Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915012/
https://www.ncbi.nlm.nih.gov/pubmed/28980850
http://dx.doi.org/10.1080/15548627.2017.1385674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915012/
https://www.ncbi.nlm.nih.gov/pubmed/28980850
http://dx.doi.org/10.1080/15548627.2017.1385674

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