Combination of interferon-expressing oncolytic adenovirus with chemotherapy and radiation is highly synergistic in hamster model of pancreatic cancer

Recent clinical trials utilizing Interferon-alpha (IFN) in combination with chemoradiation have demonstrated significant improvements in the survival of patients with pancreatic cancer. However, efficacy was limited by the systemic toxicity of IFN and low intratumoral levels of the cytokine. We soug...

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Detalles Bibliográficos
Autores principales: Salzwedel, Amanda O., Han, Joohee, LaRocca, Christopher J., Shanley, Ryan, Yamamoto, Masato, Davydova, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915056/
https://www.ncbi.nlm.nih.gov/pubmed/29719589
http://dx.doi.org/10.18632/oncotarget.24710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915056/
https://www.ncbi.nlm.nih.gov/pubmed/29719589
http://dx.doi.org/10.18632/oncotarget.24710

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