Cargando…

A Jurkat 76 based triple parameter reporter system to evaluate TCR functions and adoptive T cell strategies

Adoptive T cell therapy using TCR transgenic autologous T cells has shown great potential for the treatment of tumor patients. Thorough characterization of genetically reprogrammed T cells is necessary to optimize treatment success. Here, we describe the generation of triple parameter reporter T cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rosskopf, Sandra, Leitner, Judith, Paster, Wolfgang, Morton, Laura T., Hagedoorn, Renate S., Steinberger, Peter, Heemskerk, Mirjam H.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915142/ https://www.ncbi.nlm.nih.gov/pubmed/29707134 http://dx.doi.org/10.18632/oncotarget.24807

Ejemplares similares

A CD22-reactive TCR from the T-cell allorepertoire for the treatment of acute lymphoblastic leukemia by TCR gene transfer
por: Jahn, Lorenz, et al.
Publicado: (2016)

Extracellular Domains of CD8α and CD8ß Subunits Are Sufficient for HLA Class I Restricted Helper Functions of TCR-Engineered CD4(+) T Cells
por: van Loenen, Marleen M., et al.
Publicado: (2013)

Generation of a Jurkat-based fluorescent reporter cell line to evaluate lipid antigen interaction with the human iNKT cell receptor
por: Humeniuk, Piotr, et al.
Publicado: (2019)

Publisher Correction: Generation of a Jurkat-based fluorescent reporter cell line to evaluate lipid antigen interaction with the human iNKT cell receptor
por: Humeniuk, Piotr, et al.
Publicado: (2019)

CTLA-4 antibody ipilimumab negatively affects CD4(+) T-cell responses in vitro
por: Rosskopf, Sandra, et al.
Publicado: (2019)

Combining BCMA-targeting CAR T cells with TCR-engineered T-cell therapy to prevent immune escape of multiple myeloma
por: Wachsmann, Tassilo L. A., et al.
Publicado: (2023)

Generation of CD20-specific TCRs for TCR gene therapy of CD20(low) B-cell malignancies insusceptible to CD20-targeting antibodies
por: Jahn, Lorenz, et al.
Publicado: (2016)

Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure
por: Wachsmann, Tassilo L. A., et al.
Publicado: (2022)

Lck Mediates Signal Transmission from CD59 to the TCR/CD3 Pathway in Jurkat T Cells
por: Lipp, Anna M., et al.
Publicado: (2014)

Reprogramming of Virus-specific T Cells into Leukemia-reactive T Cells Using T Cell Receptor Gene Transfer
por: Heemskerk, Mirjam H.M., et al.
Publicado: (2004)

Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2
por: Bray, Cara, et al.
Publicado: (2018)

Targeting CAR to the Peptide-MHC Complex Reveals Distinct Signaling Compared to That of TCR in a Jurkat T Cell Model
por: Wu, Ling, et al.
Publicado: (2021)

4‐1BB costimulation promotes bystander activation of human CD8 T cells
por: Reithofer, Manuel, et al.
Publicado: (2020)

Broadly applicable TCR-based therapy for multiple myeloma targeting the immunoglobulin J chain
por: Meeuwsen, Miranda H., et al.
Publicado: (2023)

T Cell Receptor (TCR)-induced Tyrosine Phosphorylation Dynamics Identifies THEMIS as a New TCR Signalosome Component
por: Brockmeyer, Claudia, et al.
Publicado: (2011)

Expression of Non-T Cell Activation Linker (NTAL) in Jurkat Cells Negatively Regulates TCR Signaling: Potential Role in Rheumatoid Arthritis
por: Narbona-Sánchez, Isaac, et al.
Publicado: (2023)

A T‐cell reporter platform for high‐throughput and reliable investigation of TCR function and biology
por: Müller, Thomas R, et al.
Publicado: (2020)

Generating HPV specific T helper cells for the treatment of HPV induced malignancies using TCR gene transfer
por: Scholten, Kirsten BJ, et al.
Publicado: (2011)

Human iPSC-derived preclinical models to identify toxicity of tumor-specific T cells with clinical potential
por: van Amerongen, Rosa A., et al.
Publicado: (2023)

A Highly Sensitive Cell-Based TLR Reporter Platform for the Specific Detection of Bacterial TLR Ligands
por: Radakovics, Katharina, et al.
Publicado: (2022)

PRAME and HLA Class I expression patterns make synovial sarcoma a suitable target for PRAME specific T-cell receptor gene therapy
por: Luk, Sietse J, et al.
Publicado: (2018)

Engineering Strategies to Enhance TCR-Based Adoptive T Cell Therapy
por: Rath, Jan A., et al.
Publicado: (2020)

A human monocytic NF-κB fluorescent reporter cell line for detection of microbial contaminants in biological samples
por: Battin, Claire, et al.
Publicado: (2017)

TCR-NK Cells: A Novel Source for Adoptive Immunotherapy of Cancer
por: Karahan, Zeynep Sena, et al.
Publicado: (2023)

S76. Adoptive cell therapy of melanoma with autologous tumour infiltrating lymphocytes
por: Svane, I, et al.
Publicado: (2014)

Opium Induces Apoptosis in Jurkat Cells
por: Igder, Somayeh, et al.
Publicado: (2013)

“First AID” for T cell adoptive transfer: TCR affinity maturation by somatic hypermutation
por: Gozlan, Yosi M, et al.
Publicado: (2013)

Generation of TCRα-transduced T cells for adoptive transfer therapy of salmonellosis in mice
por: Kalinina, Anastasiia, et al.
Publicado: (2021)

Molecular Analysis of Elements of Melanoma Insensitivity to TCR-Engineered Adoptive Cell Therapy
por: Jazirehi, Ali R.
Publicado: (2021)

Trial Watch: Adoptive TCR-Engineered T-Cell Immunotherapy for Acute Myeloid Leukemia
por: Campillo-Davo, Diana, et al.
Publicado: (2021)

TCR-engineered adoptive cell therapy effectively treats intracranial murine glioblastoma
por: Schaettler, Maximilian O, et al.
Publicado: (2023)

An HLA-A*11:01-Binding Neoantigen from Mutated NPM1 as Target for TCR Gene Therapy in AML
por: van der Lee, Dyantha I., et al.
Publicado: (2021)

A cellular platform for the evaluation of immune checkpoint molecules
por: Jutz, Sabrina, et al.
Publicado: (2017)

Neuropilin-1 Acts as a Receptor for Complement Split Products
por: Battin, Claire, et al.
Publicado: (2019)

SARS-CoV-2-specific CD4(+) and CD8(+) T cell responses can originate from cross-reactive CMV-specific T cells
por: Pothast, Cilia R, et al.
Publicado: (2022)

Blocking TCR restimulation induced necroptosis in adoptively transferred T cells improves tumor control
por: Kesarwani, Pravin, et al.
Publicado: (2016)

Apoptosis is associated with triacylglycerol accumulation in Jurkat T-cells
por: Al-Saffar, N M S, et al.
Publicado: (2002)

Low seroprotection rate for meningococcus serogroup C in the adult HIV-1-infected population in Austria
por: Grabmeier-Pfistershammer, Katharina, et al.
Publicado: (2019)

Effect of Light Irradiation and Sex Hormones on Jurkat T Cells: 17β-Estradiol but Not Testosterone Enhances UVA-Induced Cytotoxicity in Jurkat Lymphocytes
por: Cohly, Hari H.P., et al.
Publicado: (2005)

The Phosphotyrosine Phosphatase SHP-2 Participates in a Multimeric Signaling Complex and Regulates T Cell Receptor (TCR) coupling to the Ras/Mitogen-activated Protein Kinase (MAPK) Pathway in Jurkat T Cells
por: Frearson, Julie A., et al.
Publicado: (1998)

Cannot write session to /tmp/vufind_sessions/sess_hbohju86k34gclc6fljaht0s2t