Improvement of kynurenine aminotransferase-II inhibitors guided by mimicking sulfate esters

The mammalian kynurenine aminotransferase (KAT) enzymes are a family of related isoforms that are pyridoxal 5’-phosphate-dependent, responsible for the irreversible transamination of kynurenine to kynurenic acid. Kynurenic acid is implicated in human diseases such as schizophrenia where it is found...

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Detalles Bibliográficos
Autores principales: Jayawickrama, Gayan S., Nematollahi, Alireza, Sun, Guanchen, Church, William Bret
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915280/
https://www.ncbi.nlm.nih.gov/pubmed/29689093
http://dx.doi.org/10.1371/journal.pone.0196404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915280/
https://www.ncbi.nlm.nih.gov/pubmed/29689093
http://dx.doi.org/10.1371/journal.pone.0196404

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