Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage-and Histone Methylation-Dependent Pathways

Polycomb group (PcG) factors maintain facultative heterochromatin and mediate many important developmental and differentiation processes. EZH2, a PcG histone H3 lysine-27 methyltransferase, is repressed in senescent cells. We show here that downregulation of EZH2 promotes senescence through two dist...

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Detalles Bibliográficos
Autores principales: Ito, Takahiro, Teo, Yee Voan, Evans, Shane A., Neretti, Nicola, Sedivy, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915310/
https://www.ncbi.nlm.nih.gov/pubmed/29590617
http://dx.doi.org/10.1016/j.celrep.2018.03.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915310/
https://www.ncbi.nlm.nih.gov/pubmed/29590617
http://dx.doi.org/10.1016/j.celrep.2018.03.002

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