Longitudinal two-photon imaging in somatosensory cortex of behaving mice reveals dendritic spine formation enhancement by subchronic administration of low-dose ketamine

Ketamine, a well-known anesthetic, has recently attracted renewed attention as a fast-acting antidepressant. A single dose of ketamine induces rapid synaptogenesis, which may underlie its antidepressant effect. To test whether repeated exposure to ketamine triggers sustained synaptogenesis, we admin...

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Detalles Bibliográficos
Autores principales: Pryazhnikov, Evgeny, Mugantseva, Ekaterina, Casarotto, Plinio, Kolikova, Julia, Fred, Senem Merve, Toptunov, Dmytro, Afzalov, Ramil, Hotulainen, Pirta, Voikar, Vootele, Terry-Lorenzo, Ryan, Engel, Sharon, Kirov, Sergei, Castren, Eero, Khiroug, Leonard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915413/
https://www.ncbi.nlm.nih.gov/pubmed/29691465
http://dx.doi.org/10.1038/s41598-018-24933-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915413/
https://www.ncbi.nlm.nih.gov/pubmed/29691465
http://dx.doi.org/10.1038/s41598-018-24933-8

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