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Alternative polyadenylation drives genome-to-phenome information detours in the AMPKα1 and AMPKα2 knockout mice

Currently available mouse knockout (KO) lines remain largely uncharacterized for genome-to-phenome (G2P) information flows. Here we test our hypothesis that altered myogenesis seen in AMPKα1- and AMPKα2-KO mice is caused by use of alternative polyadenylation sites (APSs). AMPKα1 and AMPKα2 are two α...

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Detalles Bibliográficos
Autores principales: Zhang, Shuwen, Zhang, Yangzi, Zhou, Xiang, Fu, Xing, Michal, Jennifer J., Ji, Guoli, Du, Min, Davis, Jon F., Jiang, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915415/
https://www.ncbi.nlm.nih.gov/pubmed/29691479
http://dx.doi.org/10.1038/s41598-018-24683-7