The Neutral Sphingomyelinase 2 Is Required to Polarize and Sustain T Cell Receptor Signaling

By promoting ceramide release at the cytosolic membrane leaflet, the neutral sphingomyelinase 2 (NSM) is capable of organizing receptor and signalosome segregation. Its role in T cell receptor (TCR) signaling remained so far unknown. We now show that TCR-driven NSM activation is dispensable for TCR...

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Detalles Bibliográficos
Autores principales: Börtlein, Charlene, Draeger, Annette, Schoenauer, Roman, Kuhlemann, Alexander, Sauer, Markus, Schneider-Schaulies, Sibylle, Avota, Elita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915489/
https://www.ncbi.nlm.nih.gov/pubmed/29720981
http://dx.doi.org/10.3389/fimmu.2018.00815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915489/
https://www.ncbi.nlm.nih.gov/pubmed/29720981
http://dx.doi.org/10.3389/fimmu.2018.00815

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