Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase

Many non-histone proteins are lysine methylated and a novel function of this modification is to trigger the proteolysis of methylated proteins. Here, we report that the methylated lysine 142 of DNMT1, a major DNA methyltransferase that preserves epigenetic inheritance of DNA methylation patterns dur...

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Detalles Bibliográficos
Autores principales: Leng, Feng, Yu, Jiekai, Zhang, Chunxiao, Alejo, Salvador, Hoang, Nam, Sun, Hong, Lu, Fei, Zhang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915600/
https://www.ncbi.nlm.nih.gov/pubmed/29691401
http://dx.doi.org/10.1038/s41467-018-04019-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915600/
https://www.ncbi.nlm.nih.gov/pubmed/29691401
http://dx.doi.org/10.1038/s41467-018-04019-9

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