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Inhibitors of both the N-methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases
The Jumonji C (JmjC) family of 2-oxoglutarate (2OG)-dependent oxygenases have established roles in the regulation of transcription via the catalysis of demethylation of Nε-methylated lysine residues in histone tails, especially the N-terminal tail of histone H3. Most human JmjC N(ɛ)-methyl lysine de...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915715/ https://www.ncbi.nlm.nih.gov/pubmed/29685975 http://dx.doi.org/10.1098/rstb.2017.0071 |