Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors

The clinical severity and annual occurrence of influenza virus epidemics, combined with the availability of just a single class of antivirals to treat infections, underscores the urgent need to develop new anti-influenza drugs. The endonuclease activity within the viral acidic polymerase (PA) protei...

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Detalles Bibliográficos
Autores principales: Jones, Jeremy C., Kumar, Gyanendra, Barman, Subrata, Najera, Isabel, White, Stephen W., Webby, Richard J., Govorkova, Elena A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Observation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915737/
https://www.ncbi.nlm.nih.gov/pubmed/29691337
http://dx.doi.org/10.1128/mBio.00430-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915737/
https://www.ncbi.nlm.nih.gov/pubmed/29691337
http://dx.doi.org/10.1128/mBio.00430-18

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