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Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors

The clinical severity and annual occurrence of influenza virus epidemics, combined with the availability of just a single class of antivirals to treat infections, underscores the urgent need to develop new anti-influenza drugs. The endonuclease activity within the viral acidic polymerase (PA) protei...

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Detalles Bibliográficos
Autores principales:	Jones, Jeremy C., Kumar, Gyanendra, Barman, Subrata, Najera, Isabel, White, Stephen W., Webby, Richard J., Govorkova, Elena A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Observation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915737/ https://www.ncbi.nlm.nih.gov/pubmed/29691337 http://dx.doi.org/10.1128/mBio.00430-18

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