Second-generation CK2α inhibitors targeting the αD pocket

CK2 is a critical cell cycle regulator that also promotes various anti-apoptotic mechanisms. Development of ATP-non-competitive inhibitors of CK2 is a very attractive strategy considering that the ATP binding site is highly conserved among other kinases. We have previously utilised a pocket outside...

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Detalles Bibliográficos
Autores principales: Iegre, Jessica, Brear, Paul, De Fusco, Claudia, Yoshida, Masao, Mitchell, Sophie L., Rossmann, Maxim, Carro, Laura, Sore, Hannah F., Hyvönen, Marko, Spring, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916021/
https://www.ncbi.nlm.nih.gov/pubmed/29732088
http://dx.doi.org/10.1039/c7sc05122k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916021/
https://www.ncbi.nlm.nih.gov/pubmed/29732088
http://dx.doi.org/10.1039/c7sc05122k

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